Novel Compounds that Target Mycobacteria and Other Pathogenic Bacteria
11-038-dowd - Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is one of the deadliest infectious diseases. Emergence of drug resistant strains of Mtb and co-infection with HIV has made...
View ArticleThinking outside the heart: Use of engineered cardiac tissue for treatment of...
013-042-sarvazyan - Researchers at George Washington University invented a new organ that can return blood flow to veins lacking functioning valves. The organ is a rhythmic cuff made of cardiac muscle...
View ArticleAntisense RNA therapy for liver carcinoma
014-022-kumar - A GW researcher invented a nucleic acid based therapy for Hepatitis C Virus (HCV) infection associated hepatocellular carcinoma (HCC, liver cancer). Currently available antiviral drugs...
View ArticleIntranasal Oxytocin Therapy for Obstructive Sleep Apnea
015-001-mendelowitz - Obstructive sleep apnea (OSA) is a health risk that occurs in 24% of males and 9% of females in the United States. OSA can lead to several cardiovascular diseases including...
View ArticleDiagnostic method for detecting bacterial/viral infections by host RNA levels...
015-030-mccaffrey - In instances of respiratory distress, it is often difficult to determine whether an infection is present or if the distress is purely inflammatory in nature. Treatments for these...
View Article3D printed vascularized tissue scaffold with extracellular matrix triggered...
016-006-zhang - “Vas-Scaf” is a 3D bio-printed vascularized bone scaffold perfused with osteogenic and angiogenic growth factors. Artificial bone grafts lacking vascularization fail due to poor...
View ArticleNew Use for Small Molecule to Kill Malaria Parasites
015-050-dowd - GW researchers synthesized the new small molecule, RCB-185, and initially showed efficacy against Mycobacterium tuberculosis (Mtb), but now demonstrate much higher efficacy against...
View ArticleVital Ring: a Wearable Wireless Multiple-Lead ECG Sensor Embedded in a...
015-025-li - Patients at risk of adverse cardiac events can benefit from mobile, on-demand, or real-time monitoring of their heart rhythms. Patient data can help diagnose symptoms of cardiac...
View Article3D Printing Blood Vessels Without Sacrificial Templates
017-011-zhang - Using novel bioactive ink for 3D printing, GW researchers create multi-layered vasculature. Large-scale artificial tissue implants for defect reconstruction require vascularization to...
View ArticleMatrix-free Mass Spectrometry on Nanopost Array (NAPA) Chips
009-000xb-vertes - Silicon NAPA chips provide highly efficient ion production for ultratrace analysis and molecular imaging by mass spectrometry without an ionization matrix. Matrix-assisted laser...
View ArticleCombining Dual 3D Bioprinting and Regional Bioactive Factors to Make...
016-025-zhang - GW researchers generated a vascularized and highly osteogenic bone construct with a biphasic structure using a multiple 3D printing platform. Traditional tissue engineering techniques...
View ArticleIntranasal Oxytocin to Treat Heart Failure
017-033-kay - Heart failure (HF) results in imbalance of the cardiac autonomic system, i.e. increased sympathetic activity and decreased parasympathetic activity. The present therapies for heart...
View ArticleMitoScope: Minimally Invasive Device for Measuring the Energy Production Rate...
017-004-kay - The minimally invasive MitoScope assesses the metabolic rate of heart tissue in vivo, non-destructively, and in real-time. MitoScope measures the mitochondrial enzyme activity of the...
View ArticleMicrobubble and Ultrasound Therapies to Enhance Cartilage Repair and Regrowth
017-022-sarkar - By combining low intensity pulsed ultrasound (LIPUS) with lipid coated microbubbles, researchers at GW increased differentiation of human mesenchymal stem cells (hMSCs) into cartilage....
View Article3D Shape Memory Scaffolds for Tissue Engineering
016-005-zhang - Over 120,000 patients are currently waiting for lifesaving organ and tissue transplants. Tissue engineering has the potential to innovate transplant and minimally invasive surgery by...
View ArticleLaser Ablation Electrospray Ionization (LAESI) Mass Spectrometry: matrix-free...
006-000x-vertes - LAESI provides very precise in situ chemical analysis of biological samples using mass spectrometry (MS) technique. LAESI enables 2D and 3D imaging of metabolites, lipids, peptides...
View ArticleJAK2 Inhibition to Treat Platinum Resistant Ovarian Cancer
017-038-zhu - Researchers at GW overcame platinum drug resistance in ovarian cancer by combining JAK2 inhibitor LY2784544 with standard platinum based chemotherapeutics. Doctors commonly prescribe...
View ArticleIn vitro drug treatment to proliferate and activate effector cells for...
018-063-bosque - STAT5 SUMOylation inhibition increases CD4 and CD8 T-cell proliferation and and production of immune effector molecules in CD8 T-cells and NK (natural killer) cells. Both attributes...
View ArticleTherapeutics to prevent HIV-associated Coronary Artery Disease
016-022-bukrinsky-nef-inhibitor - HIV-infected patients have high risk of coronary artery disease (CAD). Previously, GW researchers identified HIV regulatory protein Nef as a causative factor in foam...
View ArticleThick 3D Bioprinted Cardiac Patch with Anisotropic and Perfusable Vessels
018-012-zhang - GW researchers fabricated a vascularized patch of cardiac tissue suitable for cardiac regeneration using 3D bioprinting. Cardiovascular disease involving myocardial infarction is a...
View Article(Technology Bundle) Stem cells with transiently reduced p53 to treat diabetes...
018-044-sen-019-54-sen - Local delivery of endothelial progenitor cells (EPCs) may treat diabetic-related kidney disease (DKD) and peripheral vascular disease (PVD). EPCs may be obtained from a...
View ArticleAnd-1 Inhibition by DHS for Cancer Treatment
017-039-zhu - GW researchers developed DHS (4,4’-trans-dihydroxystilbene) as a new cytotoxic anticancer drug for use alone or in combination with other chemotherapies. Drug toxicity and drug resistance...
View Article4D-Printed Programmable Culture Substrate for Controlling Neural Stem Cell...
020-006-zhang - Neural stem cells (NSCs) exhibit great promise for treating neurodegenerative diseases and injuries. Treatments will rely on efficient proliferation and differentiation of NSCs into...
View ArticleHDAC6i-Activated Macrophage Cell Therapy
019-057-villagra - The tumor microenvironment (TME) plays a key role in tumor growth and survival. Often the immunosuppressive nature of the TME prevents success of treatments including immune...
View ArticleHighly Potent and Selective HDAC6 Inhibitor for Cancer Treatment
020-031-villagra - GW and UIC researchers developed a highly potent Histone Deacetylase (HDAC) inhibitor. HDACs can modulate a multitude of cellular processes and are a part of the regulation of...
View ArticleNon-Invasive Plasma Discharge Tube Device for Treating Brain Tumors
019-062-keidar - Treating brain tumors, like glioblastoma, is challenging. Current glioblastoma drugs, Rapamycin and Temozolomide (TMZ), generally only extend life for a matter of months, are not very...
View ArticleAntibiotic for Veterinary Staphylococcal Infections
018-033-dowd - New bacteriostatic compounds treat Staphylococcal strains that infect bovine, cat, and dog populations. Staphylococcal infections affect an estimated 20% of bovine populations in the...
View ArticleDiagnostic for Hidradenitis Suppurativa using Dermicidin Peptide Secretion in...
019-010-shanmugam - Hidradenitis Suppurativa (HS) is a common chronic disease wherein painful boils and lesions develop owing to the inflammation of sweat glands. The boils develop in the armpits,...
View Article3D Biophotonic Devices for All Optical Electrophysiology
021-036-entcheva - Optical actuation and sensing methods were demonstrated by GW for high-throughput drug and cardiotoxicity screening. However, modification of target cells takes time, has variable...
View ArticleImmunotherapies Targeting SSX2 Peptide Displayed by MHC on Tumors
019-066-yvon - Chimeric Antigen Receptor (CAR) T cells are making headlines with their recent FDA approvals and ability to eradicate cancers. Most CAR T therapies target tumor cells via a tumor...
View Article
